• A novel, data-driven logistic regression model (LIFE-5S) was developed and validated to predict 5-year mortality after transvenous lead extraction (TLE).
  • Unlike previous models that focused mainly on early or in-hospital mortality, LIFE-5S extends prognostic assessment to long-term outcomes.
  • LIFE-5S demonstrated excellent discrimination (AUC=0,787) and calibration in both derivation and validation cohorts, enabling practical application in patient counseling, risk stratification, and post-TLE management.
  • the LIFE-5S model provides accurate, individualized prediction of 5-year mortality after TLE useful for decision-making and patient follow-up after TLE.
  • Moreover, in a wide range of non-infectious indications for TLE having 2B class – shared decision-making and special situations (abandoned lead, abandoned system, downgrading, upgrading, prophylactic lead replacement) the final decision should take into account the chances of long-term survival but so far we have not had an appropriate tool to make prognosis. Therefore, there is a clear clinical need for a simple, data-driven, and validated predictive model that integrates both clinical and procedural parameters to provide individualized risk assessment for long-term survival following transvenous lead extraction.